Oxford’s Malaria Vaccine Receives WHO Prequalification


  • WHO prequalifies R21/Matrix-M malaria vaccine for broader entry
  • It’s the second WHO-prequalified malaria vaccine after RTS,S/AS01
  • Vaccines are essential in stopping malaria, particularly in African areas with excessive little one mortality

Malaria, which claims the lives of practically half one million youngsters yearly within the African area alone, faces a promising adversary because the World Well being Group (WHO) bestows prequalification standing upon the R21/Matrix-M malaria vaccine. It’s a groundbreaking improvement within the quest for efficient malaria prevention. The vaccine, developed by Oxford College and manufactured by the Serum Institute of India, has been added to WHO’s prestigious checklist of prequalified vaccines (1 Trusted Supply
WHO recommends groundbreaking malaria vaccine for kids in danger

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This resolution, made in October 2023, follows the advice by the WHO Strategic Advisory Group of Specialists (SAGE) on Immunization and the Malaria Coverage Advisory Group. The R21 vaccine’s prequalification is a major stride ahead within the ongoing efforts to forestall malaria, particularly in youngsters.


What’s Malaria?

Malaria, a mosquito-borne illness, imposes a considerable burden on youngsters within the African area, the place practically half one million youngsters succumb to the illness yearly. In 2022 alone, the world witnessed an estimated 249 million malaria circumstances, leading to 608,000 malaria-related deaths throughout 85 international locations.


Vaccine for Malaria Prevention in Youngsters

The R21/Matrix-M vaccine now joins the ranks of the RTS,S/AS01 vaccine, turning into the second malaria vaccine to realize prequalification from the WHO. The RTS,S/AS01 vaccine obtained this standing in July 2022. WHO’s prequalification holds great significance, because it opens up avenues for wider entry to vaccines, positioning them as key instruments within the prevention of malaria in youngsters. It serves as a prerequisite for vaccine procurement by organizations like UNICEF and secures funding help for deployment by Gavi, the Vaccine Alliance.

Each the R21 and RTS,S/AS01 vaccines have demonstrated security and efficacy by rigorous medical trials, instilling confidence of their capability to forestall malaria in youngsters. The pre-qualification course of by WHO includes a complete analysis of vaccines based mostly on worldwide requirements to determine their security, effectiveness, and adherence to manufacturing benchmarks. This course of ensures that vaccines utilized in world immunization packages meet the required standards throughout the focused well being techniques.


Malaria Vaccine Receives WHO Prequalification

Rogério Gaspar, the director of WHO’s Division of Regulation and Prequalification, emphasizes the importance of attaining WHO vaccine prequalification. He states that this achievement ensures vaccines are protected and efficient throughout the situations of their use within the focused well being techniques. WHO’s dedication to evaluating a number of merchandise for prequalification annually underscores its dedication to offering larger entry to protected, efficient, and high quality well being merchandise worldwide.

As a part of the prequalification course of, WHO frequently screens the protection and efficacy of prequalified vaccines. This includes common re-evaluation, web site inspections, and focused testing to take care of the excessive requirements anticipated of those vaccines. The method additionally takes into consideration the particular wants of nationwide immunization packages, contemplating components resembling efficiency, thermostability, presentation, labeling, and delivery situations.

Embracing a Malaria-Free World with R21/Matrix-M Vaccine

The R21/Matrix-M vaccine’s prequalification marks a considerable step ahead within the struggle towards malaria, providing hope for enhanced safety, particularly for susceptible populations like youngsters in malaria-endemic areas. This achievement aligns with WHO’s broader mission to fight infectious illnesses globally and underscores the significance of worldwide collaboration in addressing public well being challenges. The momentum gained by this prequalification units the stage for elevated accessibility and deployment of malaria vaccines, bringing us nearer to the aim of a malaria-free world.


  1. WHO recommends groundbreaking malaria vaccine for kids in danger – (https://www.who.int/information/merchandise/06-10-2021-who-recommends-groundbreaking-malaria-vaccine-for-children-at-risk)



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