Migraines Improve Threat of Being pregnant Problems

“Preterm supply and hypertensive problems are a few of the main drivers of maternal and toddler morbidity and mortality,” mentioned Alexandra Purdue-Smithe, affiliate epidemiologist at Brigham and teacher in Drugs at Harvard Medical Faculty. “Our findings recommend {that a} historical past of migraine warrants consideration as an vital threat issue for these problems and might be helpful in flagging girls who could profit from enhanced monitoring throughout being pregnant,” Purdue-Smithe added.

Girls are two to 3 instances extra doubtless than males to endure from migraines all through their lifetime, and complications are commonest between the ages of 18 and 44 when girls are most fertile.

Aura (5.5% of the inhabitants) can accompany migraine complications, that are sometimes visible abnormalities that develop earlier than headache onset.

The researchers evaluated knowledge from the Nurses’ Well being Research II, which comprised 30,555 pregnancies from 19,694 U.S. nurses, for this examine. The researchers examined pre-pregnancy self-reported physician-diagnosed migraine and migraine phenotype (migraine with and with out aura), in addition to the incidence of self-reported being pregnant outcomes.


Pre-pregnancy migraine was discovered to be linked with a 17% greater threat of preterm supply, a 28% greater fee of gestational hypertension, and a 40% greater fee of preeclampsia in comparison with no migraine.

Migraine with aura was linked to an elevated incidence of preeclampsia in comparison with migraine with out aura.

Aspirin Use Linked with Preterm Supply

Contributors with migraines who reported common aspirin use — greater than twice weekly — earlier than being pregnant had a forty five% decreased threat for preterm supply. People at excessive threat of preeclampsia and people with a couple of intermediate threat issue for preeclampsia ought to take low-dose aspirin all through being pregnant, in line with the US Preventive Providers Activity Pressure.

Low-dose aspirin throughout being pregnant has additionally been present in scientific trials to cut back untimely delivery charges. Nevertheless, Purdue-Smithe identified that migraines will not be among the many indications for aspirin use throughout being pregnant.

“Our findings of decreased threat of preterm supply amongst girls with migraine who reported common aspirin use earlier than being pregnant means that aspirin can also be useful for ladies with migraine,” Purdue-Smithe mentioned. “Given the observational nature of our examine, and the shortage of detailed info on aspirin dosage out there within the cohort, scientific trials might be wanted to definitively reply this query.”

Supply: Medindia


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