Is Stronger Therapy Mandatory for Girls With Hardened Arteries?

“The research suggests {that a} given burden of atherosclerosis is riskier in postmenopausal ladies than it’s in males of that age,” stated research creator Dr. Sophie van Rosendael of Leiden College Medical Centre, the Netherlands. “Since atherosclerotic plaque burden is rising as a goal to determine the depth of remedy to stop coronary heart assaults, the findings might impression therapy” (


in what is known as plaque. Whereas younger ladies do have coronary heart assaults, normally, ladies develop atherosclerosis later in life than males and have coronary heart assaults at an older age than males (

), partially due to the protecting impact of estrogen. This research examined whether or not the prognostic significance of atherosclerotic plaques are the identical for men and women at totally different ages as this may very well be vital for choosing remedies to stop coronary heart assaults.

The research included 24,950 sufferers referred for coronary computed tomography angiography (CCTA) and enrolled within the CONFIRM registry, which was performed in six international locations in North America, Europe, and Asia. CCTA is used to acquire 3D photographs of the arteries within the coronary heart.


Whole atherosclerotic burden was rated utilizing the Leiden CCTA rating, which contains the next gadgets for every coronary section: plaque presence (sure/no), composition (calcified, noncalcified or blended), location, and severity of narrowing, for a last worth of 0 to 42. Sufferers had been divided into three classes beforehand discovered to foretell the chance myocardial infarction: low atherosclerotic burden (0 to five), medium (6 to twenty) and excessive (over 20). As well as, obstructive coronary artery illness was outlined as 50% narrowing or extra.

The first final result was the distinction in Leiden CCTA rating between men and women of comparable age. The investigators additionally analysed intercourse variations within the charges of main antagonistic cardiovascular occasions (MACE), which included all-cause demise and myocardial infarction, after adjusting for age and cardiovascular danger components (hypertension, excessive ldl cholesterol, diabetes, present smoking and household historical past of coronary artery illness).

Atherosclerosis in Girls

A complete of 11,678 ladies (common age 58.5 years) and 13,272 males (common age 55.6 years) had been adopted for 3.7 years. Relating to the first final result, the research confirmed an roughly 12 yr delay within the onset of coronary atherosclerosis in ladies: the median Leiden CCTA danger rating was above zero at age 64 to 68 years in ladies versus 52 to 56 years in males (p<0.001). As well as, the general plaque burden as quantified by the Leiden CCTA rating was considerably decrease in ladies, who had extra non-obstructive illness.

Dr. van Rosendael stated: “The outcomes verify the beforehand reported delay within the begin of atherosclerosis in ladies. We additionally discovered that girls usually tend to have non-obstructive illness. It was previously thought that solely obstructive atherosclerosis prompted myocardial infarction however we now know that non-obstructive illness can be dangerous.”

The burden of atherosclerosis was equally predictive of MACE in premenopausal ladies (aged below 55 years) and males of the identical age group. Nevertheless, in postmenopausal ladies (age 55 years and older), the chance of MACE was greater than males for a given rating. In postmenopausal ladies, in comparison with these with a low burden, these with a medium and excessive burden had 2.21-fold and 6.11-fold greater dangers of MACE. Whereas in males aged 55 years and older, in comparison with these with a low burden, these with a medium and excessive burden had 1.57-fold and a couple of.25-fold larger dangers of MACE.

Dr. van Rosendael stated: “On this research, the elevated danger for girls versus males was particularly noticed in postmenopausal ladies with the best Leiden CCTA rating. This may very well be partly as a result of the inside diameter of coronary arteries is smaller in ladies, that means that the identical quantity of plaque might have a bigger impression on blood circulate.”

References :

  1. Computerised tomography angiography within the coronary heart of cardioavascular imaging – (

  2. Intercourse and age-specific interactions of coronary atherosclerotic plaque onset and prognosis from coronary computed tomography – (

  3. International Use of Methods To Open Occluded Coronary Arteries IV-Acute Coronary Syndrome – (

Supply: Eurekalert


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