Is Delaying Antibiotics Good for Neutropenic Fever in Most cancers

A fever in a affected person with neutropenia is taken into account a medical emergency. The fever indicators a extreme lower in neutrophils and subsequently a compromised capacity of the immune system to chase away infections.

Neutropenic fever is outlined as a temperature of not less than 101°, or a sustained temperature of not less than 100.4° for an hour or extra.

The Infectious Illness Society of America and the American Society of Medical Oncology have each revealed tips for treating outpatients who’ve neutropenic fever.


Each organizations name for administering an intravenous antibiotic inside 60 minutes after the fever is detected. The advice about antibiotics can be usually utilized to the therapy of hospital inpatients, however there is not any clear and acceptable proof.

Pointers for Treating Outpatients might not Apply to Hospitalized Sufferers

For proof, researchers seemed again at information on 187 sufferers at their hospital who had developed a neutropenic fever. Their fundamental aim was to see whether or not delays in antibiotic therapy affected short-term survival.

Solely 14% of sufferers acquired antibiotics inside 60 minutes of creating a neutropenic fever. Their survival charge 6 months later wasn’t considerably higher than the survival charge of sufferers who acquired antibiotics later than beneficial.

Even a delay of greater than 4 hours wasn’t lengthy sufficient to have an effect on survival. This result’s in line with data from earlier research of inpatients.

Researchers consider present therapy tips are acceptable for sufferers with neutropenic fever who’re handled in a doctor’s workplace or an emergency division, however different elements should be thought-about for sufferers who’ve been admitted to a hospital.

In contrast to neutropenic fever sufferers presenting to the emergency division, the place true time to antibiotic administration might usually be many hours and even days earlier than arrival, a number of hours lengthy [delay] within the hospital will not be sufficiently lengthy sufficient to trigger vital affected person hurt.

Supply: Eurekalert


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