Hyperlink to Traumatic Mind Damage and Dementia?

Traumatic mind accidents are strongly related to an elevated threat of dementia. Sadly, the precise pathways underlying this relationship are unclear. This hole in data makes it troublesome to create preventative methods to help sufferers with TBI.

CSF leaks are related to decreased mind buoyancy and the looks of mind sagging on MRI. Extreme mind sagging might trigger signs that mimic these of a behavioral variant of frontotemporal dementia (bvFTD), a sort of early-onset dementia. A latest publication by Schievink and colleagues discovered {that a} kind of spinal CSF leak known as CSF-venous fistula is frequent amongst sufferers with signs of bvFTD. As soon as recognized by means of a specialised imaging method referred to as digital subtraction myelography, surgical correction of the leak resulted in decision of the dementia signs amongst all 9 eligible sufferers within the research who had frontotemporal mind sagging syndrome.

“After I learn Schievink et al.’s research, a light-weight went off in my head,” says senior writer Professor Esme Fuller-Thomson, “I questioned if these CSF leaks may very well be an essential contributing issue within the well-established hyperlink between traumatic mind harm and dementia. The rationale that that is so thrilling is that if this speculation is true, it’s potential that treating the leak might mitigate dementia signs in some sufferers with a historical past of TBI.” Dr. Fuller-Thomson is the director of College of Toronto’s Institute of Life Course and Growing older and a Professor within the Issue-Inwentash College of Social Work and Division of Household and Group Drugs.

Managing Extreme CSF Leaks

Signs of extreme CSF leaks embrace headache, disequilibrium, and hypersomnolence. Whereas many CSF leaks might resolve on their very own, bigger leaks might require surgical ligation by means of a minimally invasive process. Figuring out the supply of CSF leaks may be troublesome, however specialised imaging modalities, such because the digital subtraction myelography utilized by Schievink et al., could also be useful.


“We hope that different researchers are equally intrigued by the potential significance of CSF leaks within the affiliation between TBI and dementia and that additional analysis exploring this affiliation will likely be performed,” says co-author Judy Deng, a pharmacist from the College of Toronto.

Fuller-Thomson provides, “This speculation is, in fact, excessive speculative and we want way more analysis to find out if it holds any promise.”

Supply: Eurekalert


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