Enhanced Efficacy of Morning-After Capsule With Anti-Inflammatory Painkiller

The findings indicated that the piroxicam-levonorgestrel co-treatment prevented a considerably increased share of pregnancies (94.7%) in comparison with levonorgestrel alone (63.4%). There have been no notable variations in hostile results, together with adjustments in menstrual bleeding patterns and abdomen discomfort between the 2 regimens. The examine was revealed in a current concern of The Lancet.

Emergency contraception is a contraceptive methodology that can be utilized to stop an unintended being pregnant when a daily contraceptive methodology fails or will not be used. It may be within the type of an oral emergency contraceptive capsule or the insertion of a copper intrauterine contraceptive gadget (Cu-IUD).


The oral levonorgestrel emergency contraceptive capsule is likely one of the hottest decisions of emergency contraception and is broadly utilized in most nations. It was pioneered by a scientific trial in Hong Kong led by HKUMed’s Professor Ho Pak-chung, revealed in 1993. Nonetheless, all contraceptive strategies have a failure price. Therefore, the analysis crew is constant its efforts to discover more practical choices.

Prostaglandins are substances produced by most physique tissues in people and mediate quite a few organic processes, together with inflammatory responses. Within the reproductive system, prostaglandin is a crucial mediator of processes like ovulation, fertilisation and embryo implantation. The analysis crew postulated that including a drugs that blocks prostaglandin synthesis might have an extra complimentary impact in reaching contraception.

Chief-investigator Dr Raymond Li Dangle-wun, from HKUMed, mentioned, ‘Our examine is the primary to seek out that piroxicam, a available medicine, taken similtaneously the levonorgestrel capsule can forestall extra pregnancies than levonorgestrel alone. We hope these findings will result in additional analysis and finally adjustments in scientific pointers to allow ladies all over the world to entry more practical emergency contraception.’

Co-investigator Dr Sue Lo Seen-tsing, from FPAHK, mentioned, ‘The levonorgestrel capsule was registered in Hong Kong in 2002 and has been used safely since then. Regionally, emergency contraceptives should be prescribed by healthcare suppliers, who assess which emergency contraceptive methodology is essentially the most appropriate in every case.

Contraceptive counselling needs to be supplied to assist ladies in search of emergency contraception perceive that it can not exchange common contraceptives and to inspire them to make use of the latter. Since there’s nonetheless a small failure price, a follow-up go to is essential. The levonorgestrel emergency contraception capsule needs to be taken inside 72 hours after unprotected intercourse; the sooner it’s taken, the more practical it’s.’

Supply: Eurekalert


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