Cystatin C Protein Acts as a Biomarker to Calculate Kidney Perform

Investigators on the Brigham checked out 1,783 inpatients and outpatients who had cystatin C and creatinine ranges drawn inside 24 hours from January 1, 2018 till September 9, 2020. They evaluated how cystatin C eGFR correlated with creatinine eGFR and the way it indicated variations in CKD staging.

They discovered that cystatin C-based eGFR was strongly correlated with creatinine-based eGFR and that 27 % of sufferers could be categorized as having a extra extreme continual kidney stage based mostly on cystatin C take a look at outcomes; the chance of getting a change in stage was larger amongst sufferers who had kidney operate on the border between phases.

Cystatin C as a Marker for GFR

Researchers additionally discovered that Black sufferers have been much less prone to be reclassified to a extra extreme stage than White sufferers, however there have been limitations within the self-identified race information. These outcomes are vital, as Black, Hispanic, and Native American sufferers have been proven to have much less well timed nephrology referrals, transplant entry, residence dialysis therapy and elevated development to kidney failure.


“Nationally, there needs to be a concentrate on making this vital take a look at inexpensive and accessible to a large, various spectrum of sufferers,” mentioned Mallika Mendu, MD, Affiliate Chief Medical Officer, Affiliate Professor of BWH’s Nephrology Division, and senior creator of the research.

Supply: Eurekalert


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